Dissolution Solutions Network

News, Stories and Commentary from the Pharma Lab

Effects of sinker shapes on dissolution profiles

“In dissolution testing, according to the U.S. Pharmacopeia, a nonreactive stainless steel wire helix is typically used to sink dosage forms that would otherwise float. The objective of this investigation was to determine if other sinker shapes will influence the rate, extent, or variability of dissolution. Criteria for the optimal sinker were … more“

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